Topic: advanced parental age

The progressive increase in parental age at conception and its impact on the offspring's well-being has concerned researchers about possible adverse outcomes. Studies have reported a wide range of health risks, including genetic abnormalities, psychiatric morbidity and neurodegeneration, in the offspring born to aged parents. Indeed, a few studies from animal models show the trans-generational effects of advanced parental age (APA). We, therefore, aimed to understand if APA affects the overall fitness of offspring in F1 and F2. We have used Drosophila (Canton S) as a model system for this. The