The role of noradrenaline in medial forebrain bundle deep brain stimulation: A physiological and anatomical approach
Zhuo Duan, Yixin Tong, Volker Coenen, Máté Döbrössy · FENS Forum 2024
Deep brain stimulation (DBS) targeting the medial forebrain bundle (MFB) is emerging as a promising intervention for treatment-resistant depression. Our study systematically investigated the NA system in a depression model and explored the modulatory effects of mfb-DBS on this system.Using Flinders Sensitive Line (FSL) rats as a depression model and Sprague Dawley (SD) rats as controls, we examined the spatial distribution and myelination of NA fibers within the mfb under confocal microscopy, monitored real-time in vivo NA release in response to mfb-DBS in the mPFC and NAC during 6 different s
ePoster · Neuroscience