The intrinsic properties of somatostatin interneurons in a Mecp2-deficient mouse model of Rett syndrome
Abinayah John, Asma Soltani, Ole Paulsen · FENS Forum 2024
Rett syndrome (RTT) is a devastating neurodevelopmental disorder primarily affecting females, characterised by the loss of motor skills and behavioural abnormalities linked to an excitatory/inhibitory imbalance involving GABA dysfunction. GABAergic deficits, particularly in somatostatin (SST) interneurons, play a crucial role in RTT pathophysiology and have been successfully replicated in mouse models. This study delves deeper into understanding the role of GABAergic interneuron inhibition in an RTT mouse model. Neonatal injections were administered to Mecp2tm1.1Bird x Sst-IRES-Cre mice at P1,
ePoster · Neuroscience