The calcium link uncovered: Investigating TRPC3 and SKCa channels interaction
Hazel Erkan-Candag, Anna Wulz, Perrine Royal, Guillaume Sandoz, Klaus Groschner, Oleksandra Tiapko · FENS Forum 2024
Ca2+-permeable transient receptor potential canonical 3 (TRPC3) channel is involved in memory modulation by regulating the excitability of hippocampal neurons, contributing to enhanced afterhyperpolarization (AHP). Calcium-activated potassium channels are fundamental modulators of neuronal excitability and contribute to the generation of AHPs following action potential bursts. TRPC3 channels enhance the activity of Ca2+-dependent K+ channels by local, microdomain communication.To uncover downstream targets of TRPC3 signaling in hippocampal neurons, we performed electrophysiological recordings,
ePoster · Neuroscience