Targeted perturbation of endogenous mechanisms for the regulation of perineuronal nets
Guro Vatne, Sverre Grødem, Tina Kleven, Tor Solesvik Oppedal, Ingeborg Nymoen, Elise Holter Thompson, Kristian Lensjø, Torkel Hafting, Marianne Fyhn · FENS Forum 2024
Perineuronal nets (PNNs), a specialized form of the extracellular matrix, enwrap subtypes of neurons and have many proposed functions including regulating adult brain plasticity. Removal of PNNs in adult mice by the bacterial enzyme chondroitinase ABC restores brain plasticity levels to that of juveniles. However, chondroitinase ABC indiscriminately degrades all chondroitin sulfate proteoglycans in the extracellular matrix, its effect is not restricted to PNNs. In contrast, several endogenous metalloproteinases specifically target PNN components. Some of these are selectively expressed in PNN-
ePoster · Neuroscience