Behavioral, electrophysiological and enzymatic characterization of new preclinical rodent model exposed to different sub-lethal doses of soman
Rosalie Bel, Assia Belkebir, Lucie Lepinard, Alexandre Champault, Julie Knoertzer, Karine Thibault, Grégory Dal Bo · FENS Forum 2024
Soman stands as a prominent nerve agent in preclinical investigations focusing on neuroprotection. Analogous to its organophosphorus counterparts, soman manifests heightened toxicity through cholinesterase inhibition, instigating a consequential cholinergic crisis. Its pronounced capacity to phosphonylate the catalytic serine of acetylcholinesterase (AChE) triggers the aging reaction, hindering AChE reactivation. Consequently, the development of effective antidotes for soman emerges as a challenge. While acute effects of soman exposure, with high doses, have been extensively scrutinized, there
ePoster · Neuroscience