Unbiased whole-brain screens identify an agranular insula to basolateral amygdala projection that mediates pain hypersensitivity
May Hui, Gregory Corder, Kevin Beier · FENS Forum 2024
Despite the pervasiveness of chronic pain worldwide, few effective strategies for long-term pain management exist. The development of new, non-addictive pain interventions hinges upon a deeper understanding of the changes in neural activity and circuitry that drive the development of chronic pain states. Recent studies have implicated the basolateral amygdala (BLA) as a critical hub in the encoding of negative valence to nociceptive information. Using immediate early gene mapping in combination with an activity-based rabies viral tracing screen, we identified several brain regions that synapse
ePoster · Neuroscience