Topic: Ai9

Neuropsychiatric disorders affect approximately 1 in 8 people globally, stemming from a complex interplay of genetics and environment, including copy number variations like the 15q13.3 microdeletion associated with heightened risks of schizophrenia and autism. Limited medication options coupled with social, cognitive, and adaptive challenges hinder the integration of affected individuals into society due to insufficient understanding of underlying pathophysiological mechanisms. To address this, we developed a triple transgenic mouse model combining the 15q13.3+/- microdeletion with TRAP2;Ai9,