The air we breathe, the brain we have
Giulia Terribile, Sara Di Girolamo, Silvia Sesana, Francesca Re, Paolo Spaiardi, Gerardo Biella, Giulio Alfredo Sancini · FENS Forum 2024
Epidemiological studies put in evidence how the brain is emerging as an important target for adverse health effects of airborne pollutants (AP). We thus investigated the direct effect of AP on hCMEC/D3, astrocytes, microglia (MG) and neurons using the standard reference material of diesel exhaust particles (DEP). To study the DEP impact on purinergic signalling, we compared untreated primary MG with those incubated with DEP. Our data showed that DEP-activated MG generated much smaller ATP-induced Ca2+ waves, revealing a significant suppression of the receptor-evoked Ca2+ signals. The same resu
ePoster · Neuroscience