Diiodothyropropionic acid facilitates oligodendrocyte differentiation and myelination to enhance neuroprotection and neurorepair in the central nervous system
Rahimeh Emamnejad, Steven Petratos, Ezgi Ozturk, Maurice Pagnin · FENS Forum 2024
In multiple sclerosis (MS), oligodendrocyte (OL) degeneration and subsequent demyelination in the central nervous system (CNS) causes neurological impairment. Monocarboxylate transporter 8 (MCT8) may promote OL maturation and myelination by actively transporting thyroid hormone (TH) into the CNS and thereby facilitating key transcription and metabolomic pathways for myelin biogenesis. Diiodothyropropionic acid (DITPA), a synthetic TH-analog, can be transported into the CNS, independent of MCT8 and may promote OL maturation and myelination. In this study, we investigated the potential of DITPA
ePoster · Neuroscience