Is dysfunctional neuronal differentiation the link between diet and neurodegeneration?
Imogen Targett, Tim Craig · FENS Forum 2024
Type 2 diabetes mellitus (T2DM) is associated with a nearly 2-fold increased risk of Alzheimer's disease (AD) development although the reasons for this are unknown. Recent studies have reported dysregulated hippocampal neurogenesis in AD patients during postmortem examinations. Additionally, impaired neurogenesis has been observed in T2DM mouse models, suggesting this could explain the connection between T2DM and AD. This study aims to investigate how exposure to fatty acids associated with T2DM affects neuronal differentiation, serving as a model of neurogenesis. Human SH-SY5Y neuroblastoma c
ePoster · Neuroscience