Regulation of fear-related behavior by cortical metabotropic glutamate 5 receptors (mGluR5)
Pawel Matulewicz, Arnau Ramos-Prats, Sabine Schönherr, Amadeu Llebaria, Xavier Gómez-Santacana, Francesco Ferraguti · FENS Forum 2024
Aims: Metabotropic glutamate 5 receptors (mGluR5) signaling pathway has been implicated in the maintenance of the excitation/inhibition (E/I) balance in neuronal networks, and thus to contribute to appropriate processing of emotional information and regulation of fear-related behavior. However, numerous gaps remain in our current knowledge of the neural substrates of fear, in particular, the assessment of the role of those receptors in one of the central nodes of the brain neurocircuitry for fear, namely the medial prefrontal cortex (mPFC). The aim of this study was to assess the impact of pho
ePoster · Neuroscience