Neural dynamics of choice behavior: Influence of prior choices on basal ganglia-anterolateral motor cortex (ALM) circuitry and optogenetic modulation of the indirect pathway
Anya Stetsenko, Maria Nunes, Faith Remias, Reina Macalindong, Tibor Koos · FENS Forum 2024
This study addresses the question of how previous choices affect the interaction between the basal ganglia and anterolateral motor cortex (ALM) during a cued auditory dual choice task in mice. We did Ca imaging in the ALM and used ChR2 for excitation of neurons in the indirect pathway. We discovered that optogenetic manipulation's impact varied with the animal's past decisions. Notably, trials following the same choice were less influenced by optogenetic stimulation, suggesting a form of neural adaptation or memory effect within the circuit. Our analysis shows distinct activity patterns in the
ePoster · Neuroscience