Topic: alpha-1-adrenoceptor

Rebound depolarization (RD) is a form of membrane depolarization triggered in some neurons following hyperpolarization. Typically, a series of action potentials are evoked during RD plateau. RD converts an inhibitory signal arriving to the neuron into an excitation signal, which is subsequently synaptically transmitted to other cells. The nature of RD in cortical neurons has been tested for several years without satisfactory explanation. The aim of our study was to evaluate the influence of adrenergic receptors activation in RD generation. Alpha-1, alpha-2, and beta-receptors have been tested.