Escitalopram and galantamine in combination modulate alpha-7 nicotinic receptor and ameliorate chronic unpredictable mild stress-induced depression-like behaviour in mice
Shivanshu Bajaj, Radhakrishnan Mahesh · FENS Forum 2024
Depressive disorders are the leading cause of the neuropsychiatric disparity, and the lack of understanding of the causes and treatment of these disorders progresses toward therapeutic failure. Current treatment approaches only provide symptomatic relief but fail to cure the underlying pathophysiology. The present study aimed to investigate the antidepressant effect of escitalopram (ESC) and galantamine (GAL) combination in vivo on a chronic unpredictable mild stress (CUMS)-induced depression in mice and further explored its mechanism of action around cAMP, BDNF-related neurotrophic signaling,
ePoster · Neuroscience