Endogenous alpha-Synuclein is essential for the transfer of pathology by exosome-enriched extracellular vesicles, following inoculation with preformed fibrils in vivo
Katerina Melachroinou, Georgios Divolis, George Tsafaras, Mantia Karampetsou, Sotirios Fortis, Yannis Stratoulias, Gina Papadopoulou, Anastasios G. Kriebardis, Martina Samiotaki, Kostas Vekrellis · FENS Forum 2024
The main pathological hallmark of Parkinson’s disease (PD) and related synucleinopathies is the presence of intracellular proteinaceous aggregates, enriched in the presynaptic protein alpha-Synuclein (α-Syn). α-Syn association with exosomes has been previously documented both as a physiological process of secretion and as a pathological process of disease transmission, however, critical information about the mechanisms governing this interplay is still lacking. To address this, we utilized the α-Syn preformed fibril (PFF) mouse model of PD, as a source of brain-derived exosome-enriched extrace
ePoster · Neuroscience