Psychosocial and physical stress modulate noradrenergic signaling in the ventral tegmental area-nucleus accumbens circuit
Zuzanna Sulich, Jakub Bilnicki, Aleksandra Kaczmarska, Joanna Bernacka, Michał Kiełbiński, Wojciech Solecki · FENS Forum 2024
Stress induces catecholaminergic system adaptations implicated in the etiology of stress-related disorders. Adrenergic receptors (ARs) in the ventral tegmental area (VTA) regulate phasic dopamine (DA) release in the mesolimbic system, associated with stress-related behavioral responses. Recently we demonstrated that intra-VTA ALPHA2-ARs (but not ALPHA1-ARs) modulation of such DA release is altered by acute stress (electric footshock). However, effects of different kind of stressors (e.g. psychosocial vs physical) on intra-VTA ALPHA2-AR signaling remains to be demonstrated.We studied the impact
ePoster · Neuroscience