Targeting cerebellar, alpha6-containing GABA-A receptors with novel compounds based on computational pharmacophore screening as potential therapy for essential tremor
Elena Battaglin, Martin Hochwarter, Jörg Heider, Thierry Langer, Petra Scholze, Margot Ernst, Xenia Simeone · FENS Forum 2024
Y-Aminobutyric acid type A (GABA-A) receptors are GABA-gated ion channels that are assembled of 5 (out of a set of 19) subunits, with six possible different alpha subunits. These differently assembled subunits lead to receptors with unique pharmacological and physiological properties that also show unique anatomical distribution. Animal models of several neuropsychiatric conditions suggest that compounds selectively activating, or positively modulating, cerebellar alpha6-containing GABA-A receptors can have highly beneficial effects on different diseases. For the case of essential tremor, flum
ePoster · Neuroscience