Overgeneralization of negative memories is a cognitive feature and predisposing factor for depression. Variable aversive events promote both memory overgeneralization and depression. However, the underlying mechanisms connecting memory generalization to depression remain unclear. Here, we demonstrate that mice that undergo two contextual fear conditionings (CFC) in altered, but not the same context, exhibit generalization of fear memories and depression-like behaviors. The medial prefrontal cortex (mPFC) to bed nucleus of the stria terminals (BNST) projection promotes both memory generalizatio
ePoster · Neuroscience