Topic: Amitriptyline

This study investigated the effects of pharmacologically distinct conventional antidepressants (amitriptyline, moclobemide, sertraline) and modulation of affective biases in rats. We tested each antidepressant in three different affective bias protocols (new learning protocol and modulation of negative affective biases associated with past experiences) and a reward learning assay (RLA) control. The affective bias test (ABT) requires animals to learn two independent and equal reward-value associations following control or drug treatment Any affective bias generated is quantified during a subseq