Chelerythrine chloride eliminates hypoxia-induced suppression of the AMPA neurotransmission in the visual retinocollicular pathway
Hanna Dumanska, Mukola Veselovsky · FENS Forum 2024
Identifying the mechanisms underlying the early stage of hypoxic injury of the retinocollicular neurotransmission will provide valuable insights that may be beneficial for the future intervening in visual attention and perception deficits and preventing their progressions. Previously, we have demonstrated that the protein kinase C (PKC) signaling pathway mediates hypoxia-induced LTP of NMDA retinocollicular neurotransmission. The potent and selective inhibitor of PKC - chelerythrine chloride (ChC, 5 µM) completely blocked the induction of LTP by hypoxia and even reversed already induced one. H
ePoster · Neuroscience