Lysosomes and synapses: Investigating the role of lysosomal protein CLN3 in synaptic function and homeostasis
Masood Ahmad Wani, Benedikt Grünewald, Jakob von Engelhardt · FENS Forum 2024
CLN3 is a lysosomal membrane protein whose precise function is not yet known. Recent studies propose divergent functions for CLN3; as a vesicular trafficking hub or its role in glycerophosphodiester (GPD) efflux from lysosomes. The role of CLN3 in the neurons and at the synapse remains elusive. Mutations in CLN3 gene cause Juvenile Neuronal Ceroid Lipofuscinosis (JNCL), a condition associated with learning impairments and memory deficits in affected children. Using CLN3Δex7/8 mouse model, we investigated the impact of CLN3 loss at synapses. Analysis of synaptic transmission revealed a signific
ePoster · Neuroscience