Network function and electrophysiological properties are impaired in corticomotor neurons of C9orf72 loss-of-function and gain-of-function ALS mouse models
Miranda de Saint-Rome, Zahra Dargaie, Azam Asgarihafshejani, Jessica Pressey, Janice Robertson, Melanie Woodin · FENS Forum 2024
ALS is the most common motor neuron disease in humans, whereby upper and lower motor neurons degenerate. A major hypothesis underlying the mechanistic origin of neurodegeneration in ALS postulates that cortical hyperexcitability facilitates cell death. Previous research has identified the G4C2 hexanucleotide repeat expansion in the C9orf72 gene as the most common genetic cause of ALS; however, little is known about the contribution of the C9orf72 gene to neuronal excitability and synaptic dysfunction in the primary motor cortex. Thus, using C9orf72 knockout loss-of-function (C9-KO LOF) and gai
ePoster · Neuroscience