Quantitative modelling of the intracellular biochemical mechanisms underlying long-term potentiation in a CA1 pyramidal cell spine head
Gábor Farkas, Luca Tar, Máté Mohácsi, Szabolcs Káli · FENS Forum 2024
A detailed computational model of synaptic plasticity-related intracellular signalling pathways was used to investigate the molecular mechanisms of long-term potentiation (LTP) in a spine head of a hippocampal CA1 pyramidal neuron. The biochemical model can be used to study the mechanisms of different forms of plasticity, the roles and contributions of the molecular pathways, individual molecular species, and the effects of different induction protocols and various types of neuromodulations. The goal of the present study is to describe the molecular changes underlying different forms of synapt
ePoster · Neuroscience