Prenatal ethanol exposure induces long-term hippocampal AMPAergic dysfunction
Lorenzo Curti, Lucia Caffino, Francesca Mottarlini, Beatrice Rizzi, Fernando Castillo Díaz, Alessia Costa, Virginia Sordi, Fabio Fumagalli, Alessio Masi, Guido Mannaioni, Elisabetta Gerace · FENS Forum 2024
Ethanol (EtOH) exposure during pregnancy can induce a range of physical, learning, and behavioral disorders in the newborn clinically referred as Fetal Alcohol Spectrum Disorder (FASD). Unfortunately, FASD is poorly understood, and the underlying mechanisms are not fully known. Here, we studied the role of AMPA receptors (AMPARs) in in vitro and in vivo models of prenatal alcohol exposure (PAE). For the in vitro study, immature rat organotypic hippocampal slices were exposed to EtOH (150 mM) for 7 days followed by 24 hours of withdrawal. For the in vivo study, female C57/Bl6 mice were exposed
ePoster · Neuroscience