Comparative electrophysiological analysis of αV and β3 integrin knock-out mice
Riccardo Ruggeri, Lucia Celora, Fanny Jaudon, Lorenzo A. Cingolani · FENS Forum 2024
Epilepsy and autism spectrum disorder have a high degree of comorbidity, likely due to shared underlying predisposing factors. Loss of αV and β3 integrin subunits have been implicated in the onset of epilepsy and autism, respectively. However, the role of the αVβ3 integrin receptor in these disorders remains unclear. Integrins are heterodimeric receptors involved in mechanotransduction between the extracellular matrix and the intracellular cytoskeleton. In the brain, β3 integrin forms heterodimers with αV integrin, regulating the synaptic localization of GluA2-containig AMPA receptors (AMPARs)
ePoster · Neuroscience