Topic: amyloid-beta(1-42)

Alzheimer’s disease (AD) is a neurodegenerative disease and the most common cause of dementia. Amyloidosis mediated by amyloid-beta(1-42) is a key factor in the pathophysiology of the disease. Braak staging of AD proposes that AD begins in the olfactory system, progressing then through the lateral entorhinal cortex to the hippocampus, whereupon symptoms of dementia become apparent. Intracerebral inoculation of healthy rodents with oligomeric amyloid-beta(1-42) results in impairments of hippocampal information processing and storage (doi: 10.3389/fnbeh.2015.00103).To what extent this also affec