PM20D1-derived N-acyl amino acids increase microglia association with amyloid plaques and neuronal fitness
Victoria Pozzi-Ruiz, Aida Giner de Gracia, Liliane Glauser, Mario Romani, Fatima Gunter-Rahman, Alejandro González-Ramón, Mahmood Haj-Yahya, Rajasekhar Kolla, Allison M Burns, Hilal A Lashuel, Johan Auwerx, Johannes Gräff, Jose Vicente Sanchez-Mut · FENS Forum 2024
Alzheimer’s disease (AD) is a complex disorder involving multiple genetic and non-genetic factors leading to cognitive decline and the accumulation of protein aggregates. Recently, we found that the epi-genetic regulation of Peptidase M20 Domain Containing 1 (PM20D1) modulates AD risk in humans and disease progression in mice through a still unknown mechanism. PM20D1 is an enzyme that facilitates the conjugation of N-acyl amino acids (NAAAs). However, whether NAAAs exert similar protective effects in AD remains unknown. To investigate this hypothesis, we NAAA-treated a series of AD models, and
ePoster · Neuroscience