Topic: amyloid-β oligomers

Early Alzheimer’s disease (AD) stages (that start even decades before clinical disease onset) are characterized by hippocampal dysfunction induced by amyloid-β oligomers (oAβ). Indeed, we have recently characterized hippocampal-dependent memory encoding and retrieval deficits and synaptic plasticity impairments in a non-transgenic mice model of early AD amyloidosis. Some protein changes underlying those deficits have been previously studied, but the spatial distribution within the hippocampus, and the possible sex dimorphism, has not been investigated before. Since each hippocampal part has cl