Topic: β-amyloid peptide

Alzheimer's disease (AD) is the most common form of dementia after the age of 65. Prior to cognitive impairment, this disease is characterized by a long asymptomatic phase during which dysfunctions of neurotransmission have been demonstrated. It is known that these early dysfunctions are the result of an abnormal accumulation of β-amyloid peptide which accumulates in different regions of the brain, notably the hippocampus. By performing electrophysiological recordings on the APP/PS1 transgenic mouse model that show an overproduction of β-amyloid peptide, I identified an alteration of the inhib