Virus-mediated brain-wide expression of soluble amyloid precursor protein-alpha or its bioactive C-terminal domain reverses disease-like symptoms in an Alzheimer’s disease mouse model
Yuanyuan He, Bruce Mockett, Lucia Schweitzer, Stephanie Hughes, Wickliffe Abraham · FENS Forum 2024
Soluble amyloid precursor protein-alpha (sAPPα) plays critical roles in healthy brain functions, including cognition, suggesting that it may be a useful therapeutic for the treatment of neurological disorders such as Alzheimer’s disease (AD). Recombinant adeno-associated viruses (AAV) carrying therapeutic transgenes may provide a therapeutically useful delivery strategy. Recently, modified AAV capsids have been designed that cross the blood-brain barrier (BBB) of mice and transduce cells throughout the brain. We investigated if one such capsid, AAV-PHP.eB, could deliver either the human sAPPα
ePoster · Neuroscience