Short-term CD8+ T cells ablation reduces microgliosis in the hippocampus of old APP/PS1 animals
Marco Zattoni, Rieder Sophie-Marie, Sabine Bernegger, Barbara Altendorfer, Ariane Benedetti, Heike Mrowetz, Jennifer Forster, Michael Stefan Unger, Ludwig Aigner · FENS Forum 2024
Alzheimer´s disease (AD) progression has been recently associated to the infiltration of CD8+ T cells into disease-affected brain parenchyma, where they tightly associate with microglial and neuronal structures. However, the functional role of CD8+ T cells in the AD brain is still elusive. Therefore, we investigated the impact of short-term CD8+ T cell ablation on neuroinflammation in transgenic AD mice (APP/PS1).CD8+ T cells ablation was performed via intraperitoneal injections of anti-CD8 antibody for three days in two-year-old APP/PS1 and wild-type male mice. Control groups received the res
ePoster · Neuroscience