Topic: β-amyloid plaques

Alzheimer’s disease (AD) is a devastating neurodegenerative disorder characterized by the accumulation of β-amyloid plaques and Tau-containing neurofibrillary tangles, with no effective treatment currently available. To address the complex nature of AD pathology, we investigate a "multiple drugs – multiple targets" approach leveraging miRNA-based therapeutics. miRNAs, short non-coding RNAs, offer unique potential for gene network-based therapies due to their ability to regulate multiple genes within common biological pathways. Dysregulated miR-124 and miR-132, implicated in AD pathology, prese