Role of the amyloid precursor protein in presynaptic plasticity at hippocampal mossy fiber synapses
Ana Moreira de Sá, Anaël Erhardt, Bruna Mira, Vincent Paget-Blanc, Gaël Barthet, Etienne Herzog, Christophe Mulle · FENS Forum 2024
The full-length amyloid precursor protein (APP), a key player in Alzheimer’s disease (AD), is ubiquitously expressed throughout the brain. It is known to be abundantly expressed in presynaptic compartments where it interacts with proteins of the presynaptic release machinery. However, the physiological functions of APP in the CNS still remain to be investigated. Here we study the physiological role of APP in presynaptic plasticity and information transfer within the hippocampus. We deleted APP and the related protein APLP2 in dentate gyrus granular cells (GCs) using a viral gene transfer strat
ePoster · Neuroscience