Unravelling the contribution of the APP-derived peptide AETA in Alzheimer’s disease pathology
Jade Dunot, Laurine Gonzalez, Sebastien Moreno, Carine Gandin, Agathe Launay, Sandy Ma Yishan, Ingrid Bethus, Marin Truchi, Bernard Mari, David Blum, Michael Willem, Alexis Faure, Hélène Marie · FENS Forum 2024
The amyloid-β precursor protein (APP), physiologically cleaved, allows the secretion of Amyloid-β (Aβ) but also of other peptides, including the peptides secreted from the η-secretase pathway (AETA peptides) that we described previously (Willem et al., Nature 2015, PMID:26322584). We now obtained reliable data showing that AETA controls both ionotropic and non-ionotropic signalling of NMDA receptors (NMDAr) (Dunot et al, in revision). Here we asked whether AETA, due to its new-found role as a modulator of NMDArs, could be implicated in Alzheimer’s disease (AD) aetiology. First, we quantified A
ePoster · Neuroscience