Cholinergic system and amyloid beta (Aβ) interplay at tripartite glutamatergic synapses in an alternative mouse model of Alzheimer’s disease
Manuela Tore, Nicole Tonesi, Irene Incerti, Paolo Pozzi, Miriam Cavagnini, Jonathan Mapelli, Gabriele Losi · FENS Forum 2024
Alzheimer Disease’s (AD) etiology is a hot topic in neuroscience. Cholinergic hypothesis was the earliest theory while amyloidogenic hypothesis is currently the most studied. Unfortunately, despite massive and prolonged efforts, triggering events responsible for AD genesis remain elusive. Here, we aim to elucidate the cellular and molecular mechanisms that induce AD by focusing on glutamatergic tripartite synapses in hippocampus. It is known that Aβ binds to α7 Acetylcholine nicotinic receptors (α7nAchRs) with high affinity, favoring synaptic plasticity at physiological picomolar concentration
ePoster · Neuroscience