Topic: analog spikes

Most neurons in the vertebrate nervous system communicate through action potentials that are typically considered all-or-none events, thus conveying information in a digital manner. However, recent work has suggested the possibility of non-stereotypical, hybrid analog-digital spikes (analog spikes for short) that modulate synaptic transmission, blurring the line between analog and digital signaling. In this study, we consider a model of a binomial synapse, where the probability of vesicle release is determined by a product of two factors: a binary indicator of presynaptic spiking, and a contin