Topic: androgen response elements

Androgen Receptor (AR) is a steroid hormone-activated transcription factor located in the cytoplasm in an inactive state. In response to androgen binding, AR shuttles from the cytosol to the nucleus, where it regulates the expression of specific AR target genes. AR is widely expressed throughout the brain, hippocampus, hypothalamic nuclei (like the preoptic area, POA), and amygdala. AR gene is located in the X chromosome; therefore, it is present in a single copy in men. Males lacking or expressing mutant AR display female-like external sexual organs and infertility, which are recapitulated in