Impact of social distancing on willingness to exert effort in mice of both sexes: Studies of dopamine manipulations
Paula Matas Navarro, Régulo Olivares-García, Andrea Martínez-Verdú, Carla Carratalá-Ros, Berta Catalán-Bernabeu, John D. Salamone, Mercè Correa · FENS Forum 2024
Early-life stress alters brain function and increases the risk of suffering psychiatric disorders later in life. Sustained stress affects the response of the mesolimbic dopaminergic (DA) system. That system regulates the activational component of motivated behavior, including effort-based decision-making. The aim of our study was to evaluate the impact of social distancing starting at PND28 (SD - two mice per cage separated by a wall with holes) on the willingness to exert effort during adulthood in an operant procedure. In this task, mice of both sexes were trained in different schedules that
ePoster · Neuroscience