Linking genotypic variation to neural dynamics during dexterous reaching
Reza Asri, Stefan Lemke, Jian-Zhong Guo, Juan A. Gallego, Adam H Hantman, Matthew G. Perich · COSYNE 2025
The genome governs the developmental trajectory of neural circuits [1, 2], guiding processes like neurogenesis and synaptogenesis to ultimately shape the structure of the brain. Here, we study the impact of genetic variation during development on the dynamics and geometry of neural population activity in the motor cortex (MOp) of adult mice during natural feeding behavior. We focus on autism spectrum disorder (ASD) models, many cases of which are characterized by stereotypical motor impairments [3]. Specifically, we compare neural activity during a dexterous cued self-feeding task in two trans
ePoster · Neuroscience