Influence of the balancing arm of the renin-angiotensin system on motivational behavior and nociception in mice
Paraskevas Pakataridis, Filippos Chelmis, Iliana Sorotou, Daniela Pechlivanova · FENS Forum 2024
The renin-angiotensin system (RAS) is a key regulator of body homeostasis and is involved in modulating brain functions. Two opposing arms are thought to constitute the RAS: the pressor arm consists of Ang II, and AT1 receptors, mediating vasoconstrictor, proliferative, and proinflammatory effects, and the AT2 receptor, which opposes the effects of the AT1R. The depressor arm includes angiotensin-converting enzyme type 2 (ACE2) and Ang-(1-7), which mediate vasodilatory, antiproliferative, anti-inflammatory, and neuroprotective effects through the Mas receptor (MasR). This study aimed to elucid
ePoster · Neuroscience