Characterizing double-negative neuromyelitis optica spectrum disorder: A meta-analysis
Antonio Malvaso, Giacomo Greco, Elena Ballante, Pietro Businaro, Chiara Morandi, Silvia Scaranzin, Stefano Masciocchi, Enrico Marchioni, Diego Franciotta, Matteo Gastaldi · FENS Forum 2024
Neuromyelitis-optica spectrum disorders (NMOSD) usually associate with aquaporin-4 (AQP4) or myelin oligodendrocyte glycoprotein (MOG) antibodies. Seronegative-NMOSD (SN-NMOSD) has been described, but the clinical-therapeutic profile is poorly defined.We searched PubMed, Scopus and Google Scholar databases for studies reporting SN-NMOSD patients, on which anti-MOG-Abs and AQP4-Abs were tested. PRISMA guidelines and methodological quality control were assessed. Fixed or random-effects models were used to pool results across studies.We included 36/1027 articles screened and analyzed 591 SN-NMOSD
ePoster · Neuroscience