MicroRNA-34a from GABAergic neurons of the raphe contributes to its peripheral plasma level
Elena Tittarelli, Serafina Manila Guzzo, Donald Ielpo, Elena Fiori, Carlo Cifani, Rossella Ventura, Diego Andolina, Luisa Lo Iacono · FENS Forum 2024
Aims: The identification of peripheral biomarkers of brain dysfunctions is essential to aid diagnosis and facilitate patient stratification. MicroRNAs are excellent candidate molecules to this purpose, as they can be expressed in the brain with regional and functional specificity, and they are highly stable in blood serum, unlike other RNA transcripts. Mir-34a is expressed with high specificity in a subpopulation of GABAergic neurons within the mouse Dorsal Raphe Nuclei (DRN), where it regulates GABAergic transmission in response to aversive stimuli. However, a direct connection between the br
ePoster · Neuroscience