In vitro and in vivo targeting of amyloid-beta oligomers through intrabodies: Towards an innovative gene immunotherapy for Alzheimer’s disease
Laura Coppola, Raffaella Scardigli, Elena Fiori, Sofia Mancini, Silvia Middei, Federico La Regina, Giovanni Meli, Antonino Cattaneo · FENS Forum 2024
Aim: Decrease in adult neurogenesis has been described to correlate with Alzheimer’s disease (AD) progression, and we have previously demonstrated a causal link between Amyloid-beta oligomers (AβOs) accumulation in adult neural stem cells (NSCs) and reduced subventricular zone (SVZ) neurogenesis in AD Tg2576 mouse model at pre-symptomatic stage. Here we investigated if AβOs targeting in the dentate gyrus of AD mice, both at pre-symptomatic and symptomatic stage, can rescue adult hippocampal neurogenesis (AHN) and recover AD-related memory deficits. Methods: Using a disease modifying gene-thera
ePoster · Neuroscience