Topic: anti-correlated activity

Studies have linked prenatal nicotine exposure to neurobehavioral defects, including attention deficit hyperactivity disorder, behavioral issues and depression. Nicotine binds highly to the nicotinic acetylcholine receptors (nAChRs) in the habenula, perturbing cholinergic signaling. The evolutionary conserved habenula contains the largest density of nAChRs and is known as the aversive brain due to its role in mediating stress, fear and anxiety. Our research aims to understand how cholinergic signaling modulates the activity and function of the habenula. For this aim, we have generated zebra