Topic: anti-GABABR-IgG

The G-protein coupled receptor GABAB is an important regulator of presynaptic neurotransmitter release and postsynaptic excitability. In anti-GABABR autoimmune encephalitis pathogenic autoantibodies (aAB) target the GABAB receptor, leading to various symptoms, including epilepsy, cognitive disorders, and short-term memory loss. Here we aimed at evaluating the influence of these aAB on hippocampal-dependent cognitive and epileptic pathways. We used purified patient-derived antibodies (control- and anti-GABABR-IgG) in a chronic mouse model of the disease to evaluate the memory formation via Nove