Topic: anti-inflammatory phenotype

Microglia activation is a metabolically demanding process that implies the transition to a pro- or anti-inflammatory phenotype. During inflammation, microglia undergo metabolic reprogramming to meet their energy needs. Thus, the pro-inflammatory phenotype derives its energy mainly from aerobic glycolysis, whereas the anti-inflammatory phenotype depends on oxidative phosphorylation. The modulation of metabolic pathways in activated microglia could change their phenotype. Exogenously administered agmatine pretreatment (Agm, 100 µM) modulates the Lps-activated BV-2 microglial cell line towards an