N-aglycosylated extracellular loop of the potassium channel KCNJ10 as contributor to autoimmunity in multiple sclerosis
Arnaud Nicot, Pierre-Olivier Bertho, Emilie Dugast, Alexandra Garcia, Hoa-Le Mai, Sophie Brouard, Laureline Berthelot, David-Axel Laplaud · FENS Forum 2024
Immune recognition of non-self or self proteins may be either favored or hampered by antigen posttranslational modifications such as citrullination, phosphorylation or N-glycosylation. This may contribute to autoimmunity such as in multiple sclerosis (MS), a demyelinating CNS disorder. Strikingly, the glial potassium channel KCNJ10 (Kir4.1) can exhibit low to high glycosylated forms and initial works from different laboratories identified variable proportions of MS patients harboring high levels of anti-Kir4.1 IgGs. Using a well-controlled ELISA, six percent of MS patients exhibit high seric l
ePoster · Neuroscience