Studying the effect of fosfomycin on hippocampal neurogenesis in adult rats
Tamara Fahs, Maram Chaaban, Rami Arnaout, Batoul Darwish, Alaa Elmakkawi, Nayef Saadeh, Wassim Abou-Kheir · FENS Forum 2024
Neurogenesis is primarily defined as the development of neurons, which occurs in several locations of the brain including the dentate gyrus of the hippocampus. The proliferation stage of neurogenesis is the earliest stage in which the neural stem cells (NSCs) produced can be affected by a variety of factors, such as antibiotic toxicity. Fosfomycin (FOS) is a very reactive broad-spectrum antibiotic and is commonly prescribed for urinary tract infections (UTI). Previous data from our lab indicated a serious negative effect on NSCs when FOS was administered to rats. In this study, we aim to inves
ePoster · Neuroscience