HBK-10, a multimodal compound, selectively blocks 5-HT1A receptor-mediated β-arrestin recruitment and mitigates memory deficits in mice
Klaudia Lustyk, Monika Głuch-Lutwin, Barbara Modryl, Dorota Żelaszczyk, Henryk Marona, Jacek Sapa, Karolina Pytka · FENS Forum 2024
While current antidepressants tackle depressive symptoms, they often fall short in addressing cognitive deficits associated with depression. Expanding upon our previous study on HBK-10, a multimodal compound targeting 5-HT1A receptors and demonstrating antidepressant-like properties, we now aim to investigate its procognitive potential and the underlaying mechanisms.First, we evaluated the influence of HBK-10 on ß-arrestin recruitment using CHO-K1 cells expressing the 5-HT1Areceptor. Subsequently, we conducted the Morris water maze test, employing the NMDA receptor antagonist MK-801 to induce
ePoster · Neuroscience